Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells.
Identifieur interne : 000116 ( Main/Exploration ); précédent : 000115; suivant : 000117Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells.
Auteurs : Zhengguo Zhang [République populaire de Chine] ; Lin Dong [République populaire de Chine] ; Anna Jia [République populaire de Chine] ; Xi Chen [République populaire de Chine] ; Qiuli Yang [République populaire de Chine] ; Yufei Wang [République populaire de Chine] ; Yuexin Wang [République populaire de Chine] ; Ruichen Liu [République populaire de Chine] ; Yejin Cao [République populaire de Chine] ; Ying He [République populaire de Chine] ; Yujing Bi [République populaire de Chine] ; Guangwei Liu [République populaire de Chine]Source :
- Cancers [ 2072-6694 ] ; 2020.
Abstract
The therapeutic effects of glucocorticoids on colitis and colitis-associated cancer are unclear. In this study, we investigated the therapeutic roles of glucocorticoids in acute experimental ulcerative colitis and colitis-associated cancer in mice and their immunoregulatory mechanisms. Murine acute ulcerative colitis was induced by dextran sulfate sodium (DSS) and treated with dexamethasone (Dex) at different doses. Dex significantly exacerbated the onset and severity of DSS-induced colitis and potentiated mucosal inflammatory macrophage and neutrophil infiltration, as well as cytokine production. Furthermore, under inflammatory conditions, the expression of the glucocorticoid receptor (GR) did not change significantly, while mammalian target of rapamycin (mTOR) signaling was higher in colonic epithelial cells than in colonic immune cells. The deletion of mTOR in intestinal epithelial cells, but not that in myeloid immune cells, in mice significantly ameliorated the severe course of colitis caused by Dex, including weight loss, clinical score, colon length, pathological damage, inflammatory cell infiltration and pro-inflammatory cytokine production. These data suggest that mTOR signaling in intestinal epithelial cells, mainly mTORC1, plays a critical role in the Dex-induced exacerbation of acute colitis and colitis-associated cancer. Thus, these pieces of evidence indicate that glucocorticoid-induced mTOR signaling in epithelial cells is required in the early stages of acute ulcerative colitis by modulating the dynamics of innate immune cell recruitment and activation.
DOI: 10.3390/cancers12040945
PubMed: 32290362
PubMed Central: PMC7254274
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sortKey="Cao, Yejin" sort="Cao, Yejin" uniqKey="Cao Y" first="Yejin" last="Cao">Yejin Cao</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="He, Ying" sort="He, Ying" uniqKey="He Y" first="Ying" last="He">Ying He</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, 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in Intestinal Epithelial Cells.</title><author><name sortKey="Zhang, Zhengguo" sort="Zhang, Zhengguo" uniqKey="Zhang Z" first="Zhengguo" last="Zhang">Zhengguo Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Lin" sort="Dong, Lin" uniqKey="Dong L" first="Lin" last="Dong">Lin Dong</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Jia, Anna" sort="Jia, Anna" 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China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Qiuli" sort="Yang, Qiuli" uniqKey="Yang Q" first="Qiuli" last="Yang">Qiuli Yang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Yufei" sort="Wang, Yufei" uniqKey="Wang Y" first="Yufei" last="Wang">Yufei Wang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Yuexin" sort="Wang, Yuexin" uniqKey="Wang Y" first="Yuexin" last="Wang">Yuexin Wang</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Ruichen" sort="Liu, Ruichen" uniqKey="Liu R" first="Ruichen" last="Liu">Ruichen Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Cao, Yejin" sort="Cao, Yejin" uniqKey="Cao Y" first="Yejin" last="Cao">Yejin Cao</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="He, Ying" sort="He, Ying" uniqKey="He Y" first="Ying" last="He">Ying He</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Bi, Yujing" sort="Bi, Yujing" uniqKey="Bi Y" first="Yujing" last="Bi">Yujing Bi</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Liu, Guangwei" sort="Liu, Guangwei" uniqKey="Liu G" first="Guangwei" last="Liu">Guangwei Liu</name><affiliation wicri:level="1"><nlm:affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cancers</title><idno type="ISSN">2072-6694</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The therapeutic effects of glucocorticoids on colitis and colitis-associated cancer are unclear. In this study, we investigated the therapeutic roles of glucocorticoids in acute experimental ulcerative colitis and colitis-associated cancer in mice and their immunoregulatory mechanisms. Murine acute ulcerative colitis was induced by dextran sulfate sodium (DSS) and treated with dexamethasone (Dex) at different doses. Dex significantly exacerbated the onset and severity of DSS-induced colitis and potentiated mucosal inflammatory macrophage and neutrophil infiltration, as well as cytokine production. Furthermore, under inflammatory conditions, the expression of the glucocorticoid receptor (GR) did not change significantly, while mammalian target of rapamycin (mTOR) signaling was higher in colonic epithelial cells than in colonic immune cells. The deletion of mTOR in intestinal epithelial cells, but not that in myeloid immune cells, in mice significantly ameliorated the severe course of colitis caused by Dex, including weight loss, clinical score, colon length, pathological damage, inflammatory cell infiltration and pro-inflammatory cytokine production. These data suggest that mTOR signaling in intestinal epithelial cells, mainly mTORC1, plays a critical role in the Dex-induced exacerbation of acute colitis and colitis-associated cancer. Thus, these pieces of evidence indicate that glucocorticoid-induced mTOR signaling in epithelial cells is required in the early stages of acute ulcerative colitis by modulating the dynamics of innate immune cell recruitment and activation.</div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">32290362</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>28</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Print">2072-6694</ISSN><JournalIssue CitedMedium="Print"><Volume>12</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>Apr</Month><Day>11</Day></PubDate></JournalIssue><Title>Cancers</Title><ISOAbbreviation>Cancers (Basel)</ISOAbbreviation></Journal><ArticleTitle>Glucocorticoids Promote the Onset of Acute Experimental Colitis and Cancer by Upregulating mTOR Signaling in Intestinal Epithelial Cells.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">E945</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.3390/cancers12040945</ELocationID><Abstract><AbstractText>The therapeutic effects of glucocorticoids on colitis and colitis-associated cancer are unclear. In this study, we investigated the therapeutic roles of glucocorticoids in acute experimental ulcerative colitis and colitis-associated cancer in mice and their immunoregulatory mechanisms. Murine acute ulcerative colitis was induced by dextran sulfate sodium (DSS) and treated with dexamethasone (Dex) at different doses. Dex significantly exacerbated the onset and severity of DSS-induced colitis and potentiated mucosal inflammatory macrophage and neutrophil infiltration, as well as cytokine production. Furthermore, under inflammatory conditions, the expression of the glucocorticoid receptor (GR) did not change significantly, while mammalian target of rapamycin (mTOR) signaling was higher in colonic epithelial cells than in colonic immune cells. The deletion of mTOR in intestinal epithelial cells, but not that in myeloid immune cells, in mice significantly ameliorated the severe course of colitis caused by Dex, including weight loss, clinical score, colon length, pathological damage, inflammatory cell infiltration and pro-inflammatory cytokine production. These data suggest that mTOR signaling in intestinal epithelial cells, mainly mTORC1, plays a critical role in the Dex-induced exacerbation of acute colitis and colitis-associated cancer. Thus, these pieces of evidence indicate that glucocorticoid-induced mTOR signaling in epithelial cells is required in the early stages of acute ulcerative colitis by modulating the dynamics of innate immune cell recruitment and activation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Zhengguo</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jia</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Xi</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Qiuli</ForeName><Initials>Q</Initials><AffiliationInfo><Affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yufei</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Yuexin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Ruichen</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cao</LastName><ForeName>Yejin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, Institute of Cell Biology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>He</LastName><ForeName>Ying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of 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China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>04</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Switzerland</Country><MedlineTA>Cancers (Basel)</MedlineTA><NlmUniqueID>101526829</NlmUniqueID><ISSNLinking>2072-6694</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">acute ulcerative colitis</Keyword><Keyword MajorTopicYN="N">colitis</Keyword><Keyword MajorTopicYN="N">colitis-associated cancer</Keyword><Keyword MajorTopicYN="N">epithelial cells</Keyword><Keyword MajorTopicYN="N">glucocorticoid</Keyword><Keyword MajorTopicYN="N">immune cells</Keyword><Keyword MajorTopicYN="N">inflammatory bowel diseases</Keyword><Keyword MajorTopicYN="N">mTOR</Keyword><Keyword MajorTopicYN="N">macrophages</Keyword><Keyword 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IdType="doi">10.3390/cancers12040945</ArticleId><ArticleId IdType="pmc">PMC7254274</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Aliment Pharmacol Ther. 2012 Aug;36(3):248-56</Citation><ArticleIdList><ArticleId IdType="pubmed">22690748</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2014 Sep 01;5:4696</Citation><ArticleIdList><ArticleId IdType="pubmed">25175012</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2012 May 15;188(10):4736-40</Citation><ArticleIdList><ArticleId IdType="pubmed">22504639</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Signal. 2009 Apr 21;2(67):pe27</Citation><ArticleIdList><ArticleId IdType="pubmed">19383978</ArticleId></ArticleIdList></Reference><Reference><Citation>Gastroenterol Hepatol. 2007 Feb;30(2):69-73</Citation><ArticleIdList><ArticleId IdType="pubmed">17335713</ArticleId></ArticleIdList></Reference><Reference><Citation>Gastroenterology. 1994 Dec;107(6):1643-52</Citation><ArticleIdList><ArticleId IdType="pubmed">7958674</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Gastroenterol Hepatol. 2016 Nov;13(11):654-664</Citation><ArticleIdList><ArticleId IdType="pubmed">27580687</ArticleId></ArticleIdList></Reference><Reference><Citation>Aliment Pharmacol Ther. 2010 Sep;32(5):615-27</Citation><ArticleIdList><ArticleId IdType="pubmed">20626381</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2015 Oct;15(10):599-614</Citation><ArticleIdList><ArticleId IdType="pubmed">26403194</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Adv. 2018 May 09;4(5):eaao5838</Citation><ArticleIdList><ArticleId IdType="pubmed">29750193</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2013 Dec;123(12):5001-4</Citation><ArticleIdList><ArticleId IdType="pubmed">24270416</ArticleId></ArticleIdList></Reference><Reference><Citation>Lab Invest. 1993 Aug;69(2):238-49</Citation><ArticleIdList><ArticleId IdType="pubmed">8350599</ArticleId></ArticleIdList></Reference><Reference><Citation>Expert Rev Gastroenterol Hepatol. 2015 Apr;9(4):405-15</Citation><ArticleIdList><ArticleId IdType="pubmed">25494666</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2011 Jan 27;117(4):1228-38</Citation><ArticleIdList><ArticleId IdType="pubmed">21079150</ArticleId></ArticleIdList></Reference><Reference><Citation>Cells. 2019 Nov 17;8(11):</Citation><ArticleIdList><ArticleId IdType="pubmed">31744227</ArticleId></ArticleIdList></Reference><Reference><Citation>Sci Signal. 2012 Mar 27;5(217):ra25</Citation><ArticleIdList><ArticleId IdType="pubmed">22457331</ArticleId></ArticleIdList></Reference><Reference><Citation>Ann Med. 1991 Oct;23(4):389-91</Citation><ArticleIdList><ArticleId IdType="pubmed">1930932</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2013 Sep 1;191(5):2680-90</Citation><ArticleIdList><ArticleId IdType="pubmed">23904165</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell Cycle. 2009 Nov 15;8(22):3684-7</Citation><ArticleIdList><ArticleId IdType="pubmed">19855161</ArticleId></ArticleIdList></Reference><Reference><Citation>Inflamm Bowel Dis. 2009 Jan;15(1):143-5</Citation><ArticleIdList><ArticleId IdType="pubmed">18942766</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2017 Feb 01;8:14275</Citation><ArticleIdList><ArticleId IdType="pubmed">28145433</ArticleId></ArticleIdList></Reference><Reference><Citation>Cytokine. 2020 Mar;127:154955</Citation><ArticleIdList><ArticleId IdType="pubmed">31864092</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2011 Apr 21;117(16):4273-83</Citation><ArticleIdList><ArticleId IdType="pubmed">21368289</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2015 Jul 1;195(1):339-46</Citation><ArticleIdList><ArticleId IdType="pubmed">26026060</ArticleId></ArticleIdList></Reference><Reference><Citation>Postgrad Med J. 2019 Jan;95(1119):32-40</Citation><ArticleIdList><ArticleId IdType="pubmed">30636193</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Commun. 2013;4:2508</Citation><ArticleIdList><ArticleId IdType="pubmed">24149070</ArticleId></ArticleIdList></Reference><Reference><Citation>Immunity. 2016 Jun 21;44(6):1337-49</Citation><ArticleIdList><ArticleId IdType="pubmed">27317260</ArticleId></ArticleIdList></Reference><Reference><Citation>Postgrad Med J. 2011 Mar;87(1025):215-22</Citation><ArticleIdList><ArticleId IdType="pubmed">21242575</ArticleId></ArticleIdList></Reference><Reference><Citation>FASEB J. 2013 Oct;27(10):3979-90</Citation><ArticleIdList><ArticleId IdType="pubmed">23882125</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gastrointest Surg. 2017 Oct;21(10):1675-1682</Citation><ArticleIdList><ArticleId IdType="pubmed">28819916</ArticleId></ArticleIdList></Reference><Reference><Citation>Inflamm Bowel Dis. 2019 Jan 1;25(1):56-66</Citation><ArticleIdList><ArticleId IdType="pubmed">29889235</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2007 May 15;109(10):4313-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17255352</ArticleId></ArticleIdList></Reference><Reference><Citation>J Exp Med. 2006 Aug 7;203(8):1883-9</Citation><ArticleIdList><ArticleId IdType="pubmed">16880258</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2007 Jul 26;448(7152):427-34</Citation><ArticleIdList><ArticleId IdType="pubmed">17653185</ArticleId></ArticleIdList></Reference><Reference><Citation>J Cell Physiol. 2019 Feb;234(2):1618-1629</Citation><ArticleIdList><ArticleId IdType="pubmed">30132862</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1564-9</Citation><ArticleIdList><ArticleId IdType="pubmed">26811453</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Gastroenterol Hepatol. 2016 Aug;13(8):436</Citation><ArticleIdList><ArticleId IdType="pubmed">27407042</ArticleId></ArticleIdList></Reference><Reference><Citation>iScience. 2019 Jul 26;17:190-207</Citation><ArticleIdList><ArticleId IdType="pubmed">31288154</ArticleId></ArticleIdList></Reference><Reference><Citation>Peptides. 2004 Jan;25(1):95-104</Citation><ArticleIdList><ArticleId IdType="pubmed">15003361</ArticleId></ArticleIdList></Reference><Reference><Citation>J Leukoc Biol. 2016 Dec;100(6):1349-1362</Citation><ArticleIdList><ArticleId IdType="pubmed">27462101</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2002 Jul 26;110(2):163-75</Citation><ArticleIdList><ArticleId IdType="pubmed">12150925</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2012 Apr 6;287(15):12510-9</Citation><ArticleIdList><ArticleId IdType="pubmed">22356909</ArticleId></ArticleIdList></Reference><Reference><Citation>Gut. 2005 Mar;54(3):438-9; author reply 439</Citation><ArticleIdList><ArticleId IdType="pubmed">15710996</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Invest. 2020 Apr 1;130(4):2111-2128</Citation><ArticleIdList><ArticleId IdType="pubmed">31961824</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Immunol. 2004 Jan;4(1):24-34</Citation><ArticleIdList><ArticleId IdType="pubmed">14704765</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Immunol. 2009 Jul;10(7):769-77</Citation><ArticleIdList><ArticleId IdType="pubmed">19483717</ArticleId></ArticleIdList></Reference><Reference><Citation>Int Immunopharmacol. 2009 Dec;9(13-14):1568-77</Citation><ArticleIdList><ArticleId IdType="pubmed">19788936</ArticleId></ArticleIdList></Reference><Reference><Citation>Cancer Res. 2014 Feb 1;74(3):727-37</Citation><ArticleIdList><ArticleId IdType="pubmed">24351289</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):E5076-85</Citation><ArticleIdList><ArticleId IdType="pubmed">25385646</ArticleId></ArticleIdList></Reference><Reference><Citation>Gut. 1986 Mar;27(3):309-16</Citation><ArticleIdList><ArticleId IdType="pubmed">3699552</ArticleId></ArticleIdList></Reference><Reference><Citation>Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E957-65</Citation><ArticleIdList><ArticleId IdType="pubmed">25730867</ArticleId></ArticleIdList></Reference><Reference><Citation>Blood. 2010 Jun 10;115(23):4758-69</Citation><ArticleIdList><ArticleId IdType="pubmed">20335217</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2016 Jul 2;388(10039):101-2</Citation><ArticleIdList><ArticleId IdType="pubmed">27397791</ArticleId></ArticleIdList></Reference><Reference><Citation>Aliment Pharmacol Ther. 1996;10 Suppl 2:93-8; discussion 99</Citation><ArticleIdList><ArticleId IdType="pubmed">8899107</ArticleId></ArticleIdList></Reference><Reference><Citation>Gut. 2011 Jan;60(1):130-3</Citation><ArticleIdList><ArticleId IdType="pubmed">21030524</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Biol. 2004 Jul 27;14(14):1296-302</Citation><ArticleIdList><ArticleId IdType="pubmed">15268862</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 2002 Jan 11;277(2):1538-43</Citation><ArticleIdList><ArticleId IdType="pubmed">11682470</ArticleId></ArticleIdList></Reference><Reference><Citation>J Leukoc Biol. 2014 Nov;96(5):675-84</Citation><ArticleIdList><ArticleId IdType="pubmed">24948701</ArticleId></ArticleIdList></Reference><Reference><Citation>J Immunol. 2008 Sep 1;181(5):3586-94</Citation><ArticleIdList><ArticleId IdType="pubmed">18714032</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2006 Feb 10;124(3):471-84</Citation><ArticleIdList><ArticleId IdType="pubmed">16469695</ArticleId></ArticleIdList></Reference><Reference><Citation>Inflamm Bowel Dis. 2009 Jan;15(1):150-1</Citation><ArticleIdList><ArticleId IdType="pubmed">18844216</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Immunol. 2013 Jan;43(1):219-27</Citation><ArticleIdList><ArticleId IdType="pubmed">23001956</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Immunol. 2009 May;30(5):218-26</Citation><ArticleIdList><ArticleId IdType="pubmed">19362054</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Zhengguo" sort="Zhang, Zhengguo" uniqKey="Zhang Z" first="Zhengguo" last="Zhang">Zhengguo Zhang</name></noRegion><name sortKey="Bi, Yujing" sort="Bi, Yujing" uniqKey="Bi Y" first="Yujing" last="Bi">Yujing 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first="Yuexin" last="Wang">Yuexin Wang</name><name sortKey="Wang, Yufei" sort="Wang, Yufei" uniqKey="Wang Y" first="Yufei" last="Wang">Yufei Wang</name><name sortKey="Yang, Qiuli" sort="Yang, Qiuli" uniqKey="Yang Q" first="Qiuli" last="Yang">Qiuli Yang</name><name sortKey="Zhang, Zhengguo" sort="Zhang, Zhengguo" uniqKey="Zhang Z" first="Zhengguo" last="Zhang">Zhengguo Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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